Microinjection of α-Calcitonin Gene-Related Peptide into the Hypothalamus Activates Sympathetic Outflow in Rats

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タイトル別名
  • Marked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents.
  • Marked species-difference in the vascular angiotensin II-forming enzyme pathways: human and rodents
  • Marked species-difference in the vascular angiotensin II-forming pathways: Human versus rodents
  • Marked species-difference in the vascular angiotensin Il-forming pathways: Human versus rodents

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抄録

Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 62 (2), 207-210, 1993

    公益社団法人 日本薬理学会

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