Beneficial Circulatory Effect of L-Arginine.

• Nakaki Toshio

  Department of Pharmacology, School of Medicine, Keio University

• Kato Ryuichi

  Department of Pharmacology, School of Medicine, Keio University

抄録

L-Arginine is an essential amino acid for infants and growing children. This amino acid is a substrate for at least five enzymes identified in mammals, including arginase, arginine-glycine transaminase, kyotorphine synthase, nitric oxide synthase (NOS) and arginine decarboxylase. L-Arginine exerts antihypertensive and antiproliferative effects on vascular smooth muscles. NOS and arginine decarboxylase appear to be important for the effect of L-arginine on the circulatory system, since each produces nitric oxide (NO), a potent vasodilator, and agmatine, an endogenous noncatecholamine ligand for central alpha-2 adrenoceptors, from L-arginine. Several issues must be clarified before the mechanisms by which L-arginine exerts its effects on the circulatory system can be fully understood.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 66 (2), 167-171, 1994

  公益社団法人 日本薬理学会

キーワード

• L-Arginine
• Hypertension
• Atherosclerosis
• Nitric oxide
• Agmatine

詳細情報

• CRID: 1390282679263316736
• NII論文ID: 130000840671
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.66.167
• COI: 1:CAS:528:DyaK2cXmvFWrtrw%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 7532730
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819356872?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819356872?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1995191812
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可