Effects of Long-term Progesterone Treatment on the Timing of Puberty in Female Guinea Pigs.

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  • Effects of Long term Progesterone Treat

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Long-term effects of progesterone implants on the advancement of puberty were investigated in immature female guinea pigs. A subcutaneous implant of progesterone-filled tubing was given to immature females at 1 day of age and removed at 5, 10, 15, 20, or 25 days of age. Continuous treatment with progesterone implants until 15 or 20 days of age significantly advanced the mean age at first vaginal opening (25.5 ± 0.6, n=6 and 28.3 ± 0.5 days of age, n=6, respectively) as compared with controls (35.3 ± 1.6 days of age, n=6). The mean age at first ovulation (29.8 ± 1.7 days, n=6) in females implanted until 15 days of age was also significantly earlier than controls (37.7 ± 1.9 days, n=7). Ovaries at 24 days of age taken from the animals treated with a progesterone implant until 15 days of age had a significantly higher number of preovulatory follicles as compared with controls. These results indicate that long-term treatment with progesterone during the early infant period induces precocious puberty in female guinea pigs.

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