書誌事項
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- Selective IgA deficiency in a case of systemic lupus erythematosus
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A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and responded to the treatment.<br>The persentage of E rosette-forming lymphocytes in the peripheral blood was 79% and the persentage of surface-IgA bearing cells in non E rosette-forming cells was 20%.<br>When PWM-induced IgA synthesis by lymphocytes from normal control and the patient were measured, the level of IgA was about a quarter of normal synthesis. Co-culture of T cells from normal control and B cells from the patient resulted in reduced synthesis of IgA. Co-culture of the patient T cells and normal B cells also resulted in reduced synthesis of IgA. Thus the pathogenesis of IgA deficiency in the patients may be due to both B cells and T cells dysfunction.
収録刊行物
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- 日本臨床免疫学会会誌
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日本臨床免疫学会会誌 9 (3), 224-229, 1986
日本臨床免疫学会
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詳細情報 詳細情報について
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- CRID
- 1390001204651988864
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- NII論文ID
- 130000848308
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- ISSN
- 13497413
- 09114300
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- データソース種別
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- JaLC
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