HLA Antigens in Systemic Lupus Erythematosus

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  • OBANA Mitsuo
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • MITA Seiji
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • KOHNO Michinori
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • MATSUOKA Yasuo
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • IRIMAJIRI Shoichiro
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • FUJIMORI Ippei
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • FUKUDA Junya
    Department of Pathology, Kawasaki Municipal Hospital
  • TAKATA Hajime
    Department of Laboratory for Histocompatibility and Immunology, Keio University
  • KONOEDA Yoshiki
    Department of Clinical and Research Laboratory, Kawasaki City Ida Hospital
  • SEKIGUCHI Susumu
    Department of Clinical and Research Laboratory, Kawasaki City Ida Hospital

Bibliographic Information

Other Title
  • 全身性エリテマトーデス患者におけるHLA抗原の検討

Abstract

For the purpose of studying immunogenetic factors related to disease susceptibility to systemic lupus erythematosus (SLE), HLA-A, B and DR typing was performed by the standard lymphocyte microcytotoxicity test using 247 typing antisera in 34 Japanese patients with SLE and 51 healthy individuals.<br>The results obtained were as follows: <br>1) SLE patients with proteinuria had the association with HLA-BW 35 (phenotype frequency 50.0%, Relative Risk=7.5, corrected P<0.10), compared with normal control (11.8%). SLE patients without proteinuria had the association with HLA-BW 55 (phenotype frequency 35.0%, RR=8.6, Pc<0.10), compared with normal control (5.9%).<br>2) Patients with SLE had the strong association with HLA-DRW 9 (phenotype frequency 52.9%, RR=4.6, Pc<0.025), compared with normal control (19.6%).<br>3) All of the peripheral blood lymphocytes obtained from 10 patients with SLE who had anti-RNP antibody reacted with MT 3, which was one of the B-cell alloantisera including three antibodies against HLA-DR 4, DR 7 and DRW 9.<br>4) The linkage disequilibrium between HLA-BW 61 and HLA-DRW 9 was seen in the patients with SLE.

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