腸穿孔を合併した全身性エリテマトーデスの２例

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  • Two cases of systemic lupus erythematosus complicated with intestinal perforation.

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Two cases of systemic lupus erythematosus (SLE) complicated with intestinal perforation were reported. One patient was 27-year-old female suffering from SLE for about 9 years. She recently developed various symptoms due to SLE, followed by sudden onset of abdominal pain. Steroid-pulse therapy was performed and later antibiotics were administered. In spite of intensive treatment she died from sepsis and disseminated intravascular coagulation syndrome. Histopathological study demonstrated sigmoid colon perforation and numerous vasculitis in the small vessels of the intestinal wall. The other patient was 34-year-old female who developed SLE just before 10 months. She complained of unspecific abdominal illness for 2 months and suddenly got severe abdominal pain. Intestinal perforation was diagnosed immediately and she received surgical operation. After operation her clinical course was good.<br>Only 8 cases of SLE with intestinal perforation have been reported in Japan, and we believe these two cases are of great importance to discuss.

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