EXPERIMENTAL STUDY OF β-TRICALCIUM PHOSPHATE (β-TCP)-CONTAINING TITANIUM

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  • β-TCP含有チタンの実験的研究
  • ベータ TCP ガンユウ チタン ノ ジッケンテキ ケンキュウ

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Abstract

Collection of autogenous bone requires new invasion to the other healthy area. β-TCP is replaced by bone with development of bone resorption, but the intensity of β-TCP block is insufficient. We mixed titanium powders in β-TCP powders, and produced a new mold having strong intensity sufficient enough for vertebral fusion. 100% titanium, β-TCP containing 5%, 20%, or 50% of titanium, and 100% β-TCP were implanted in the tibia of rabbits. The tibia was extripated 16 weeks after implantation, and a three-point bending test was performed. The interface of the mold and the bone was observed electron microscopically at 8 and 16 weeks after implantation. The results of three-point bending test showed that the lower β-TCP containing rate was, the more the mean stress increased. In electron microscopic observation, a space was existed between the mold and the bone, and the bone was not unioned 8 weeks after operation in both 5% and 20%β-TCP. However, 16 weeks of post-operation, this space was eliminated and the bone was unioned. But no space was existed at 8 weeks after operation in 100% β-TCP. These results suggest that the higher β-TCP-containing rate was, the more early the mold was fused and stabilized at the implanted site. If the mold is not stabilized at the implanted site, micro-movement exists for a long time period, and callus formation may be stimulated. Therefore, mean stress might have been increased by callus formation in spite of low β-TCP-containing rate. A pluck intensity not affected by callus should be determined. For this purpose, it should be evaluated in the animals implanted the mold for a long period of time.

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