Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents

• Ojewole John A.O.

  Department of Pharmacology, School of Pharmacy & Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal

• Awe Emmanuel O.

  Department of Pharmacology, School of Pharmacy & Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal

• Chiwororo Witness D.H.

  Department of Pharmacology, School of Pharmacy & Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal

抄録

The leaf of Psidium guajava Linn. (family: Myrtaceae) is used traditionally in African folk medicine to manage, control and/or treat a plethora of human ailments, including diarrhoea. In this study, we examined the antidiarrhoeal activity of Psidium guajava leaf aqueous extract (PGE) on experimentally-induced diarrhoea in rodents. PGE (50-400 mg/kg p.o.) produced dose-dependent and significant (P<0.05-0.01) protection of rats and mice against castor oil-induced diarrhoea, inhibited intestinal transit, and delayed gastric emptying. Like atropine (1 mg/kg, p.o.), PGE produced dose-dependent and significant (P<0.05-0.01) antimotility effect, and caused dose-related inhibition of castor oil-induced enteropooling in the animals. Like loperamide (10 mg/kg, p.o.), PGE dose-dependently and significantly (P<0.05-0.01) delayed the onset of castor oil-induced diarrhoea, decreased the frequency of defaecation, and reduced the severity of diarrhoea in the rodents. Compared with control animals, PGE dose-dependently and significantly (P<0.05-0.01) decreased the volume of castor oil-induced intestinal fluid secretion, and reduced the number, weight and wetness of faecal droppings. PGE also produced concentration-related and significant (P<0.05-0.01) inhibitions of the spontaneous, rhythmic, pendular contractions of the rabbit isolated duodenum. The findings of this study indicate that PGE possesses antidiarrhoeal activity, and thus lend pharmacological credence to the suggested folkloric use of the plant as a natural remedy for the treatment, management and/or control of diarrhoea in some rural communities of southern Africa.<br>

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｓｍｏｏｔｈ　Ｍｕｓｃｌｅ　Ｒｅｓｅａｒｃｈ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｓｍｏｏｔｈ　Ｍｕｓｃｌｅ　Ｒｅｓｅａｒｃｈ 44 (6), 195-207, 2008

  日本平滑筋学会

キーワード

• <i>Psidium guajava</i>
• leaf aqueous extract
• antidiarrhoeal activity

詳細情報

• CRID: 1390001205056078464
• NII論文ID: 130000860914
• DOI: 10.1540/jsmr.44.195
• ISSN: 18848796
• ISSN: 09168737
• Web Site: http://www.jstage.jst.go.jp/article/jsmr/44/6/44_6_195/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009230955
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可