Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs

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  • OGAWA Mizue
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • PARK Eun-Sil
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • KAMISHINA Hiroaki
    Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University
  • SASAKI Jun
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
  • CHANG Hye-Sook
    Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University
  • YAMATO Osamu
    Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University
  • NAKAYAMA Hiroyuki
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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  • Pathology: Immunohistochemical observation of canine degenerative myelopathy in two Pembroke Welsh Corgi dogs

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Abstract

Immunohistochemistry was performed to assess whether oxidative stress and/or denatured proteins play roles in the pathogenesis of canine degenerative myelopathy (DM). Two Pembroke Welsh Corgi (PWC) dogs with a homozygous mutation (c.118G>A) in the canine superoxide dismutase 1 (SOD1) gene were examined. The pathological features of the dogs were consistent with those of previous cases of DM in PWC. In the spinal lesions, diffuse SOD1 expression was observed in the neurons while no inclusion-like aggregates had formed, which disagreed with the findings of a previous study. A unique inducible nitric oxide synthase (iNOS) staining pattern in reactive astrocytes and a significant increase in ubiquitin immunoreactivity in the spinal lesions were also observed. These findings indicate the involvement of oxidative stress and the accumulation of ubiquitinated proteins in the pathogenesis of canine DM, whereas the role of SOD1 remains unclear.<br>

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