Anatomy: Differentiation of uterine natural killer cells in pregnant SCID (scid/scid) mice

DOI Web Site Web Site Web Site 参考文献15件 オープンアクセス
  • HIYAMA Masato
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
  • KUSAKABE Ken Takeshi
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University Laboratory of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
  • KUWAHARA Ai
    Laboratory of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
  • WAKITANI Shoichi
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
  • KHAN Hamayun
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
  • KISO Yasuo
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University Laboratory of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

書誌事項

タイトル別名
  • Differentiation of Uterine Natural Killer Cells in Pregnant SCID (scid/scid) Mice

この論文をさがす

抄録

To determine whether functional T- and B-cells can affect differentiation and/or proliferation of uterine natural killer (uNK) cells, their numbers in SCID mice (genotype, C.B.-17/Icr-scid/scid) were compared with those of control mice (genotype, C.B.-17/Icr-+/+) on days 8, 12 and 16 of pregnancy. Using biotinylated-Dolichos biflorus agglutinin (DBA) lectin staining, uNK cells can be readily classified into 4 subtypes, I to IV, from immature to mature types. The number of uNK cells was significantly lower in the decidua basalis of SCID mice than in that of control mice on day 8 of pregnancy. Particularly, the number of uNK cells of immature subtype II was significantly lower in SCID mice than in the control mice. By day 12, however, the uNK cell number in the SCID mice reached the same level as that of the control mice. It is likely that uNK cell differentiation in SCID mice was delayed during the early placentation period due to a lack of functional T and B cells.<br>

収録刊行物

参考文献 (15)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ