Neutropenia Associated with Osteomyelitis due to Hepatozoon canis Infection in a Dog

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Author(s)

    • Umeki Saori MIZUNO Takuya
    • Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
    • Baba Kenji [他] UMEKI Saori
    • Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
    • BABA Kenji
    • Laboratory of Veterinary Parasitology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
    • SADA Kumiko
    • Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
    • HIRAOKA Hiroko
    • Laboratory of Veterinary Clinical Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University
    • ENDO Yasuyuki
    • Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
    • INOKUMA Hisashi
    • Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
    • HISASUE Masaharu
    • Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
    • OKUDA Masaru
    • Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University

Abstract

A 4-year-old, intact male Shiba dog was referred to Yamaguchi University Animal Medical Center, Yamaguchi, Japan, for the following complaints: anorexia, lethargy, intermittent fever, gingival bleeding and abdominal purpura. The dog presented with persistent neutropenia. Histopathological examination of a bone marrow sample revealed round to oval structures that resembled <i>Hepatozoon</i> micromerozoites and formed a "wheel-spoke" pattern. Furthermore, mature neutrophils were observed around these structures. PCR and sequencing using bone marrow aspirate confirmed<i> Hepatozoon canis</i> (<i>H. canis</i>) infection. These findings suggest that the neutropenia observed in this case was associated with osteomyelitis due to <i>H. canis</i> infection. This is the first report of neutropenia associated with <i>H. canis</i> infection. <i>H. canis</i> infection can be included in the differential diagnosis in canine cases of neutropenia in areas where the disease is endemic.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 73(10), 1389-1393, 2011

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000868268
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    11291718
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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