Dubin-Johnson syndromeの1例

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書誌事項

タイトル別名
  • The Effect of Low Caloric Intake Test on a Case With
  • Dubin Johnson syndrome ノ 1レイ トクニ テイ カロリ
  • Dubin-Johnson syndrome
  • 特に低カロリー食試験と色素代謝について

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抄録

The low caloric intake test was performed in a case with Dubin-Jonson syndrome who did not demonstrate the secondary rise in the BSP plasma clearance test. Following the fasting test the total plasma bilirubin increased by almost 100% (mainly direct type), and a a remarkable improvement of ICG clearance was noted. Interestingly, there occurred the secondary rise in BSP in plasma after fasting.<BR>The physiological alteration which causes the secondary BSP rise fbllowing the fasting seems to be dependent on the basic metabolic defect (characteristic in Dubin-Johnson syndrome) involving excretion of conjugated BSP into bile canaliculi.<BR>Furthermore, the demonstrated concomitant improvement in ICG uptake by hepatocytes may provide additional support to the concept that uptake and excretion of anionic dyes in hepatocyte are relatively independent steps on which certain selectivity is superimposed.

収録刊行物

  • 肝臓

    肝臓 17 (5), 366-371, 1976

    一般社団法人　日本肝臓学会

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