Investigation of serum Cu, Zn-SOD concentration by ELISA and histological localization in hepatocellular carcinoma(HCC) using anti-human Cu, Zn-SOD monoclonal antibody.

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  • SAKAIDA Isao
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • OGINO Keiki
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • OKA Shinji
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • MATSUURA Shinjiro
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • YOSHIMURA Shunji
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • MATSUDA Kazuya
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • SASAKI Toshiyuki
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • YAMAMOTO Kasunari
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • ANDO Keijiro
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • FUKUMOTO Yohei
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • OKITA Kiwamu
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • OKAZAKI Yukinori
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • TAKEMOTO Tadayoshi
    The First Department of Intemal Medicine, School of Medicine, Yamaguchi University
  • UDA Taizo
    Ube Research Laboratory Ube Industries' LTD

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Other Title
  • 抗ヒトＣｕ，Ｚｎ‐ＳＯＤ（ｓｕｐｅｒｏｘｉｄｅ　ｄｉｓｍｕｔａｓｅ　ＥＣ．　１．１５．１．１．，ｃｈｒｏｍ．２１）モノクローナル抗体による肝細胞癌患者血中Ｃｕ，Ｚｎ‐ＳＯＤ濃度および組織局在に関する検討

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Abstract

Serum Cu, Zn-SOD concentration and histological localization of patients with HCC were examined using anti-human Cu, Zn-SOD monoclonal antibody. The serum Cu, Zn-SOD concentration of patients with HCC was significantly elevated compared with healthy adults and also patients with liver cirrhosis but there was no correlation between serum Cu, Zn-SOD and serum GPT, GOT, AFP values.<BR>There are many reports that diminishing amounts of Cu, Zn-SOD activity were found in tumors, but our histological results show that in about 20% of our specimens Cu, Zn-SOD was strongly stained in tumors.<BR>This may indicae that amounts of Cu, Zn-SOD were quantitatively increased in tumors.<BR>These results suggest that it is possible for Cu, Zn-SOD to be a new marker for HCC and a possible reason for the existence of anti-cancer drug resistant HCC, for example such as adriamycin which kills the tumor cells mainly with active oxygen.

Journal

  • Kanzo

    Kanzo 28 (9), 1211-1218, 1987

    The Japan Society of Hepatology

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