Ｐｏｌｙｐｒｅｎｏｉｃ　ａｃｉｄによる肝化学発がん抑制のｍｅｃｈａｎｉｓｍに関する研究

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  • Study on the mechanism of inhibition of chemical hepatocarcinogenesis by polyprenoic acid.

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To clarify the effect of polyprenoic acid (E-5166) in the process of hepatocarcinogenesis, these authors investigated cell proliferation kinetics and induction of gamma-glutamyltranspeptidase positive hyperplastic nodule (GGT positive HPN), using 5 groups, different doses and administration periods of E-5166. Analysis of cell proliferation kinetics using autoradiography (3H-thymidine) and induction of GGT positive HPN were investigated in every week until 5th week, in application of Solt & Farbers' model.<BR>In the small dose group administered in early period, DNA synthesis and induction of GGT positive HPN were suppressed exceedingly.<BR>On the other hand, in the process of normal hepatic regeneration, DNA synthesis was retarded and the time of residual hepatocytes converting G0, G1, to S phase was elongated in thegroup administered E-5166 beforehand.<BR>These observations suggest that E-5166 is a potent agent for inhibition of cell proliferation in the processes of hepatocarcinogenesis and normal hepatic regeneration.

収録刊行物

  • 肝臓

    肝臓 26 (5), 605-612, 1985

    一般社団法人　日本肝臓学会

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