肝疾患における血しょうビタミンＡ誘導体（レチノイド）の高速液体クロマトグラフィーによる測定とその臨床的意義　　特に重症肝疾患における血しょうレチニル・エステルの出現について

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タイトル別名
  • Clinical assessment of plasma retinoid concentration in patients with liver diseases. With special reference to the appearance of retinyl ester in plasma of patients with severe parenchymal damage.
  • with special reference to the appearance of retinyl ester in plasma of patients with severe parenchymal damage
  • 特に重症肝疾患における血漿レチニル・エステルの出現について

抄録

Plasma concentrations of vitamin A derivatives (retinoids) were investigated by high performance liquid chromatography in the patients with liver diseases. In all of 10 controls and in 128 out of 133 cases with liver diseases, only retinol was detectable in the plasma obtained after overnight fasting. Retinol was found to be significantly decreased in the patients with acute hepatitis, fulminant hepatitis, chronic hepatitis, liver cirrhosis and hepatocellular carcinoma as compared with control. Elevated plasma concentrations of retinol were observed in 3 cases of fatty liver. Significant correlations were obtained between plasma retinol concentration and prothrombin time, hepaplastin test, albumin, choline esterase, ICG R15 or RICG. Hence, it was suggested that plasma retinol was clinically valuable as one of indicators of functioning liver mass. In addition, the appearance of retinyl palmitate was demonstrated in LDL fraction of plasma in 4 cases with decompensated liver cirrhosis and in one case of fulminant hepatitis (subacute type), possibly due to impaired uptake of "remnant" by the damaged liver.

収録刊行物

  • 肝臓

    肝臓 26 (9), 1151-1158, 1985

    一般社団法人　日本肝臓学会

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