尿中核酸量による腎炎の新診斷法

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  • A NEW DIAGNOSTIC METHOD OF NEPHRITIS BY THE NUCLEIC ACID QUANTITY IN THE URINE
  • ニョウ チュウカクサンリョウ ニ ヨル ジンエン ノ シン シンダンホウ

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We could first discover that nephritis patients excreted a large amount of nucleic acid in their urine. By a modified Hammarsten method, we extracted the nucleic acid from the nephritis urine, which was identified by the following characterizations: the maximum absorption at 260mu, the minimum at 230mu, phosphate content 8.7%, RNA/DNA ratio 1.6, diphenylamine and orcine reaction positive, and such five bases released on hydrolysis as adenine, guanine, cytosine, thymine and uracil. We detamined colorimetlycaly this urine nucleic acid amount by the use of diphenylamine reaction in the modified Schneider fraction. This nucleic acid appears to be derived from the destroyed renal cells, which was demonstrated to be connected closely with proteine, cylinders and renal epithelium excreted into the nephritis urine. Nucleic acid was not excreted in the urine of a healthy person, nor in the urine of cystitis and urethritis. The excretion of nucleic acid is specific to nephritis and in-creases in proportion to the disease.

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