Past Medical History and Risk of Death due to Hepatocellular Carcinoma, Univariate Analysis of JACC Study Data

DOI PubMed
  • SHIBATA AKIRA
    Department of Public Health, Kurume University School of Medicine
  • OGIMOTO ITSURO
    Department of Public Health, Kurume University School of Medicine
  • KUROZAWA YOUICHI
    Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University
  • NOSE TAKAYUKI
    Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University
  • YOSHIMURA TAKESUMI
    Department of Clinical Epidemiology, Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health
  • SUZUKI HIROSHI
    Department of Public Health, Faculty of Medicine, Niigata University School of Medicine
  • IWAI NOBUO
    Chugoku Occupational Health Association
  • SAKATA RITSU
    Department of Public Health, Kurume University School of Medicine
  • FUJITA YUKI
    Department of Public Health, Kurume University School of Medicine
  • ICHIKAWA SHOKO
    Department of Public Health, Kurume University School of Medicine
  • FUKUDA KATSUHIRO
    Department of Public Health, Kurume University School of Medicine
  • TAMAKOSHI AKIKO
    Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine
  • THE JACC STUDY GROUP
    See acknowledgments for present and the past investigators involved in the JACC Study

この論文をさがす

抄録

The relationship between the past history of selected diseases and the risk of dying from hepatocellular carcinoma (HCC) was analyzed using 110, 792 cohort members (46, 465 males and 64, 327 females) recruited between 1988 and 1990 by the JACC Study (the Japan Collaborative Cohort Study for Evaluation of Cancer Risk). Significantly elevated hazard ratios (HRs) were observed in both genders for the past history of kidney diseases, liver diseases, gallstones or cholecystitis, diabetes mellitus, and blood transfusion. Further, when analyzed by age group (those 40-59 years of age were “younger” and those 60-79 years of age were “older”), although the significant associations were generally maintained, the magnitude of the HRs for liver diseases and diabetes mellitus seemed to be considerably different between the younger and older age groups for male cohort members. When the analyses were limited to cohort members without the past history of liver diseases, the past histories which had significantly elevated HRs were hypertension (HR=3.14, 95% confidence interval (Cl):1.25-7.89), diabetes mellitus (HR=4.17, 95% Cl: 1.22-14.25), and blood transfusion (HR=7.69, 95% Cl: 3.09-19.15) in the younger male age group and gallstone or cholecystitis (HR=2.58, 95% Cl: 1.11-5.98) in the older male age group. On the other hand, for females, the significantly elevated HRs were gastric or duodenal ulcer (HR=4.33, 95% Cl: 1.09-17.25) in the younger age group and diabetes mellitus (HR=6.16, 95% Cl: 2.25-16.90) and blood transfusion (HR=3.86, 95% Cl: 1.58-9.41) in the older age group. However, since the evidence from our univariate analyses might not be decisive, multivariate Cox proportional hazards models controlling for potential confounders and effect modifiers will be required to obtain more valid or unbiased hazard ratios.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ