Inhibitory effect of antineoplaston A-10 on breast cancer transplanted to athymic mice and human hepatocellular carcinoma cell lines.

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著者

    • Tsuda Hideaki
    • Antineoplaston Study Group, Kurume University School of Medicine

抄録

The inhibitory effect of Antineoplaston A-10 was tested on the growth curve of human breast cancer (R-27) serially transplanted to athymic mice and on the cell growth of human hepatocellular carcinomas (KMCH-1, KYN-1, KIM-1). Approximately 1.25% of Antineoplaston A-10 in the regular mouse diet (CE2) inhibited the growth curve significantly after 35 days treatment (p<0.05). Seventy milligrams of daily intraperitoneal administration of Antineoplaston A-10 Injection also inhibited the growth curve of R-27 after 52 days treatment (p<0.01). Histological study of tumor showed no essential difference in structure but significant decrease in number of mitoses in the Antineoplaston A-10 treated groups. The cell growth of human hepatocellular carcinoma cell lines KMCH-1, KYN-1 and KIM-1 was inhibited by Antineoplaston A-10 Injection dose dependently.

収録刊行物

  • The Kurume Medical Journal

    The Kurume Medical Journal 37(2), 97-104, 1990

    久留米大学医学部 The Kurume Medical Journal 編集部

各種コード

  • NII論文ID(NAID)
    130000888719
  • 本文言語コード
    ENG
  • ISSN
    0023-5679
  • データ提供元
    J-STAGE 
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