DNAの機能と構造を操るケミカルバイオロジー  [in Japanese] The Chemical Biology That Controls DNA Function and Structure  [in Japanese]

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Abstract

Fifty years after the discovery of the double helical structure of DNA, the complete sequence of the human genome has been determined. All genetic information, which is necessary for life, is written in 30 billion base pairs of DNA. Many diseases, including cancer, hereditary and viral diseases, can be understood at the DNA sequence level. Local DNA conformations are thought to play an important role in biological processes such as gene expression. Therefore, DNA sequences and local DNA conformation are targets of novel drugs that would precisely switch certain genes on or off. Modified bases that perform various functions can also be incorporated into defined DNA sequences. Since DNA can be amplified by PCR and in other organisms, DNA becomes a promising unit for nanotechnology applications. In this review, we focus on the sequence and conformation-specific chemical reactions that occur in DNA, and the prospective uses of the chemical biology of DNA will be discussed.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 63(10), 1016-1027, 2005

    The Society of Synthetic Organic Chemistry, Japan

Cited by:  1

Codes

  • NII Article ID (NAID)
    130000928679
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0037-9980
  • NDL Article ID
    7692723
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJPref  NDL  J-STAGE 
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