Relation between Body Size and Bone Mineral Density with special reference to Sex Hormones and Calcium Regulating Hormones in Elderly Females.
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- SHIRAKI MASATAKA
- Department of Laboratory Medicine, Tokyo Metropolitan Geriatric Hospital
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- ITO HIDEKI
- Section of Endocrinology and Metabolism, Tokyo Metropolitan Geriatric Hospital
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- FUJIMAKI HIROSHI
- Section of Endocrinology and Metabolism, Tokyo Metropolitan Geriatric Hospital
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- HIGUCHI TATSUO
- Section of Gynecology, Tokyo Metropolitan Geriatric Hospital
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抄録
We studied the relation between body size and bone mineral density in elderly females. The study included a total of 93 ambulatory females aged over 60 years. They were divided into 3 groups according to their body mass index (BMI; kg/m2): slender group with BMI<20 (n=28), normal group with BMI of 20 to 24.9 (n=43) and obese group with BMI≥25 (n=22). Fracture incidence, bone mineral density, calcium regulating hormones and steroid hormones were studied in an intergroup comparative manner. The incidence of vertebral fracture was found to be negatively correlated with BMI (the incidences of vertebral fracture in slender, normal and obese were 78.6, 48.8 and 22.7%, respectively) and bone mineral density was also BMI-related (0.390±0.016, 0.456±0.015 and 0.493±0.018g/cm2, respectively: p<0.01 in ANOVA; mean±SE). The number of years after menopause was shorter in patients with a higher BMI. There was no intergroup difference in serum levels of PTH, vitamin D and estrogens. On the other hand, serum levels of calcitonin, DHEA, DHEAS, delta-4 androstenedione and testosterone were found to be higher in subjects with a higher BMI. From the present results, it seems that bone mineral density is supported not only by weight-bearing stress upon bone, but also by serum levels of calcitonin and androgens in obese females.
収録刊行物
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- Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ Ｊａｐｏｎｉｃａ
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Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ Ｊａｐｏｎｉｃａ 38 (4), 343-349, 1991
一般社団法人 日本内分泌学会