Stimulatory Effect of Epidermal Growth Factor on the Development of Mouse Early Embryos in vitro.
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- KUO TSONG-MING
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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- TAKETANI YUJI
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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- AYABE TAKUYA
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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- TSUTSUMI OSAMU
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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- MIZUNO MASAHIKO
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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抄録
Effects of epidermal growth factor (EGF) on the development of mouse 2-cell embryos cultured in vitro were investigated. The addition of EGF at a concentration of 0.5 ng/ml enhanced the development of 2-cell embryos during 24 h of incubation. As expected, EGF stimulated the synthesis of DNA in the 2-cell embryos about 4-fold over the control. The growth-promoting effect of EGF seemed to be specific in that other growth factors, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor (PDGF), nerve growth factor (NGF) and fibroblast growth factor (FGF) had no effect on the embryonal development. The addition of EGF also increased the rate of RNA synthesis in a dose-related manner between 0.1 and 50 ng/ml. However, protein synthesis was unaffected by EGF. These results raise the possibility that EGF may participate in the process of early embryogenesis in vivo.
収録刊行物
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- Endocrinologia Japonica
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Endocrinologia Japonica 38 (5), 485-490, 1991
一般社団法人 日本内分泌学会
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詳細情報
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- CRID
- 1390001206292451456
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- NII論文ID
- 130000952460
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- NII書誌ID
- AA00635052
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- ISSN
- 21856370
- 00137219
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- PubMed
- 1726866
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可