Human Corticotropin-Releasing Hormone Test in Normal Subjects and Patients with Hypothalamic, Pituitary or Adrenocortical Disorders.

DOI Web Site PubMed 被引用文献2件
  • FUKATA JUNICHI
    Second Department of Medicine, Kyoto University School of Medicine
  • NAKAI YOSHIKATSU
    Second Department of Medicine, Kyoto University School of Medicine
  • IMURA HIROO
    Second Department of Medicine, Kyoto University School of Medicine
  • ABE KAORU
    Department of Endocrinology, National Cancer Institute
  • AONO TOSHIHIRO
    Department of Obstetrics&Gynecology, The University of Tokushima School of Medicine
  • DEMURA HIROSHI
    Department of Medicine, Tokyo Woman's Medical College
  • FUJITA TAKUO
    Third Department of Medicine, Kobe University School of Medicine
  • HIBI ITSURO
    Department of Endocrinology and Metabolism, National Children's Hospital
  • IBAYASHI HIROSHI
    Third Department of Medicine, Kyushu University School of Medicine
  • IGARASHI MASAO
    Department of Gynecology, Gunma University School of Medicine
  • IRIE MINORU
    First Department of Medicine, Toho University School of Medicine
  • IZUMI KANJI
    Department of Medicine, National Osaka Hospital
  • KAGEYAMA NAOKI
    Department of Neurosurgery, Nagoya University School of Medicine
  • KATO KIYOHIKO
    Department of Medicine, Yamanashi Medical College
  • KUMAHARA YUICHI
    Department of Medicine and Geriatrics, Osaka University School of Medicine
  • MATSUZAKI FUKASHI
    First Department of Internal Medicine, Saitama Medical Center, Saitama Medical School
  • MATSUKURA SHIGERU
    Third Department of Medicine, Miyazaki Medical College
  • MIYAII KIYOSHI
    Department of Laboratory Medicine, Osaka University School of Medicine
  • MORI SHINTAROH
    Department of Neurosurgery, The Center for Adult Diseases of Osaka
  • NAKAGAWA KOJI
    Second Department of Medicine, Hokkaido University School of Medicine
  • NAKAJIMA HIRONORI
    Department of Pediatrics, Chiba University School of Medicine
  • NIIMI MITSURO
    Department of Medicine, National Nagoya Hospital
  • OGATA ETSURO
    Fourth Department of Medicine, Tokyo University School of Medicine
  • SAITO SHIRO
    First Department of Medicine, Tokushima University School of Medicine
  • SHIMIZU NAOKATA
    Third Department of Medicine, Teikyo University School of Medicine
  • SHIZUME KAZUO
    Second Department of Medicine, Tokyo Woman's Medical College
  • TAKAHARA JIRO
    First Department of Medicine, Kagawa University School of Medicine
  • TAKAKURA KINTOMO
    Department of Neurosurgery, Tokyo University School of Medicine
  • TOMITA AKIO
    First Department of Medicine, Nagoya University School of Medicine
  • UOZUMI TOHRU
    Department of Neurosurgery, Hiroshima University School of Medicine
  • WAKABAYASHI ICHIJI
    Third Department of Medicine, Nihon Medical College
  • YANAIHARA NOBORU
    Department of Bioorganic Chemistry, University of Shizuoka School of Pharmaceutical Sciences
  • YOSHIMI TERUYA
    Second Department of Medicine, Hamamatsu University School of Medicine
  • YOSHINAGA KAORU
    Second Department of Medicine, Tohoku University School of Medicine

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Human corticotropin-releasing hormone (hCRH) test was performed in 57 normal volunteers and 102 patients with hypothalamic, pituitary and adrenocortical diseases. Intravenous bolus injection of synthetic hCRH, 100μg for adults or 1.5μg/kg for children, increased plasma ACTH and cortisol levels in about 90% of normal subjects. In 47 patients with Cushing's disease, plasma ACTH tended to show an exaggerated response to hCRH and peak ACTH was the most frequent abnormal component among the several reaction parameters. Poor responders among normal subjects and patients with Cushing's disease had significantly higher plasma cortisol levels before CRH administration. Patients with hypothalamic hypopituitarism showed exaggerated response, whereas patients with primary pituitary lesion, isolated ACTH deficiency or adrenal Cushing's syndrome showed no ACTH response. These differences in the response of patients suggest the value of the hCRH test in their differential diagnosis.

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