Biological Activity of l-alpha-hydroxy Vitamin D3 in Vitamin D Dependency

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  • TSUCHIYA YUTAKA
    The Department of Endocrinology, Tokyo Metropolitan Kiyose Children's Hospital
  • MATSUO NOBUTAKE
    The Department of Endocrinology, Tokyo Metropolitan Kiyose Children's Hospital
  • CHO HIDEO
    The Department of Endocrinology, Tokyo Metropolitan Kiyose Children's Hospital
  • TSUBOUCHI KOHJI
    The Department of Endocrinology, Tokyo Metropolitan Kiyose Children's Hospital
  • KUMAGAI MITIO
    The Department of Endocrinology, Tokyo Metropolitan Kiyose Children's Hospital

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タイトル別名
  • Biological Activity of1-alpha-hydroxy Vitamin D<SUB>3</SUB>in Vitamin D Dependency
  • Biological Activity of l alpha hydroxy

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The biological activity of 1 (OH) vitamin D3 was evaluated in 2 cases of vitamin D dependency.<BR>For the improvement of serum chemistry and increment of urinary excretion of calcium 1 (OH) vitamin D3 was 500-1000 times more active than vitamin D2.<BR>The administration of 0.05 microg/kg/day and 0.1 microg/kg/day of 1 (OH) vitamin D3 were equally effective to keep the serum chemistry within normal limits. However, urinary excretion of calcium increased to an abnormal height on 0.1 microg/kg/day of 1 (OH) vitamin D3. On the other hand, administration of0.05microg/kg/day of 1 (OH) vitamin D3 kept both serum level and urinary excretion of calcium normal.<BR>It is suggested that0.05microg/kg/day is close to the optimum requirement of 1 (OH) vitamin D3 in vitamin D dependency and this should correspond to the essential requirement of 1 (OH) vitamin D3 in man.

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