Effect of hypothalamic surgery on prolactin release induced by 5-hydroxytryptophan (5-HTP) in rats.

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Author(s)

    • Ohgo Shozo [他] OHGO SHOZO
    • Third Division, Department of Medicine, Kobe University School of Medicine|Third Division, Department of Neuropsychiatry, Kobe University School of Medicine
    • KATO YUZURU
    • Third Division, Department of Medicine, Kobe University School of Medicine|Third Division, Department of Neuropsychiatry, Kobe University School of Medicine
    • CHIHARA KAZUO
    • Third Division, Department of Medicine, Kobe University School of Medicine|Third Division, Department of Neuropsychiatry, Kobe University School of Medicine
    • IMURA HIROO
    • Third Division, Department of Medicine, Kobe University School of Medicine|Third Division, Department of Neuropsychiatry, Kobe University School of Medicine
    • MAEDA KIYOSHI
    • Third Division, Department of Medicine, Kobe University School of Medicine|Third Division, Department of Neuropsychiatry, Kobe University School of Medicine

Abstract

Intravenous injections of varying doses of 5-HTP (1, 3 and 5mg/100g body wt), a precursor of serotonin, caused a significant and dose-related increase in plasma prolactin concentrations in urethane-anesthetized rats. Increases in plasma prolactin concentrations caused by 5-HTP (1mg/100g body wt <I>iv</I>) were abolished by the concomitant administration of L-DOPA (2mg/100g body wt <I>iv</I>). Plasma prolactin levels were also significantly elevated following the injection of 5-HTP in rats with complete hypothalamic deafferentation, whereas 5-HTP had no significant effect on plasma prolactin levels in rats with extensive hypothalamic ablation. These results suggest that 5-HTP causes prolactin secretion by stimulating the serotoninergic mechanism in the hypothalamus.

Journal

  • Endocrinologia Japonica

    Endocrinologia Japonica 23(6), 485-491, 1976

    The Japan Endocrine Society

Codes

  • NII Article ID (NAID)
    130000955899
  • NII NACSIS-CAT ID (NCID)
    AA00635052
  • Text Lang
    ENG
  • ISSN
    0013-7219
  • NDL Article ID
    1799120
  • NDL Source Classification
    SC141;SC291
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z53-D60
  • Data Source
    NDL  J-STAGE 
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