Effect of hypothalamic surgery on prolactin release induced by 5-hydroxytryptophan (5-HTP) in rats.
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Intravenous injections of varying doses of 5-HTP (1, 3 and 5mg/100g body wt), a precursor of serotonin, caused a significant and dose-related increase in plasma prolactin concentrations in urethane-anesthetized rats. Increases in plasma prolactin concentrations caused by 5-HTP (1mg/100g body wt <I>iv</I>) were abolished by the concomitant administration of L-DOPA (2mg/100g body wt <I>iv</I>). Plasma prolactin levels were also significantly elevated following the injection of 5-HTP in rats with complete hypothalamic deafferentation, whereas 5-HTP had no significant effect on plasma prolactin levels in rats with extensive hypothalamic ablation. These results suggest that 5-HTP causes prolactin secretion by stimulating the serotoninergic mechanism in the hypothalamus.
- Endocrinologia Japonica
Endocrinologia Japonica 23(6), 485-491, 1976
The Japan Endocrine Society