A Female Case of Kallmann's Syndrome
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A case of 20-year-old woman with hypogonadotropic hypogonadism and anosmia is reported, since very few female cases of Kallmann's syndrome have been reported so far in Japan. Three uncles on the father's side had no children. Height was 168cm, and arm span 165cm. The olfactory test revealed complete anosmia. Bone age was 13year. Chromosome was 46 XX and normal karyotype. Basal levels of serum FSH, LH and estrogens (E<SUB>1</SUB>, <SUB>2</SUB> and <SUB>3</SUB>) were low. Serum FSH and LH levels rose slightly only after LH-RH administration, and did not increase in clomiphene test. Plasma estrogens did not increase after daily injection of 150 IU of HMG for 3 successive days. The response of serum GH to arginine infusion was normal, while that to insulin-induced hypoglycemia was poor.
- Endocrinologia Japonica
Endocrinologia Japonica 23(4), 289-293, 1976
The Japan Endocrine Society