Sex difference in development of fetal pituitary-gonadal axis;Histologic observations on the anterior pituitary in fetal rats gonadectomized in utero

DOI Web Site Web Site PubMed
  • NAKAI TOSHIAKI
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • EGUCHI YASUNOBU
    Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture
  • SAKAMOTO SHOICHI
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • KIGAWA TOMONORI
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo

書誌事項

タイトル別名
  • Sex Difference in Development of Fetal Pituitary-Gonadal Axis
  • Histologic Observations on the Anterior Pituitary in Fetal Rats Gonadectomized <I>in utero</I>

この論文をさがす

抄録

Male and female fetal rats were gonadectomized in utero on the 20th day of gestation. Two days after the operation, the pituitaries were observed histologically in order to examine the changes of the population of basophilic cells. The gonadectomy of a male fetus caused a significant increase in the per cent of basophilic cells, whereas that of a female fetus induced no significant change. Since the increase in the relative number of basophilic cells following gonadectomy has already been accepted to be intimately related to the increased production of gonadotrophic hormones, the present results strongly suggest that the feedback mechanism between the pituitary and the gonad is already operated before birth in males but not in females. There is a definite sex difference in development of the pituitary-gonadal axis during the fetal life.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ