Association between Plasma Pigment Epithelium-derived Factor Levels and Tissue Characteristics of Coronary Plaque using Integrated Backscatter Intravascular Ultrasound

• Iwata Atsushi

  Department of Cardiology, Fukuoka University School of Medicine, Japan

• Miura Shin-ichiro

  Department of Cardiology, Fukuoka University School of Medicine, Japan

• Morii Joji

  Department of Cardiology, Fukuoka University School of Medicine, Japan

• Yamagishi Sho-ichi

  Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Japan

• Saku Keijiro

  Department of Cardiology, Fukuoka University School of Medicine, Japan

Abstract

Objective Recent evidence has strongly suggested that atherosclerosis is an angiogenic disease, and PEDF may play a significant role in determining the balance of angiogenesis/antiangiogenesis during atherogenesis. Therefore, we assessed the associations among plasma levels of pigment epithelium-derived factor (PEDF), high-sensitivity C-reactive protein (hsCRP), the lipid profile and tissue characteristics of coronary plaque as assessed by integrated backscatter intravascular ultrasound (IB-IVUS).<br> Methods Fifty-two consecutive patients with stable coronary artery disease who underwent percutaneous coronary intervention were enrolled. Non-target coronary lesions with mild to moderate stenosis were measured by IB-IVUS. A total of 20 IB-IVUS images were recorded at an interval of 0.5 mm for a length of 10 mm in each plaque.<br> Results Although the percentage of plaque volume (%PV, 100×total PV/total vessel volume), percentage of lipid volume (%LV, 100×LV/PV) and percentage of fibrous volume (%FV, 100×FV/PV) were not associated with plasma log[PEDF] levels in the overall patients, in the patients without statin treatment %LV and %FV were correlated with plasma log[PEDF] levels (r=0.525, p=0.021 and r=-0.498, p=0.030, respectively).<br> Conclusion The plasma level of PEDF may be a useful biomarker for predicting the tissue characteristics of coronary plaque using IB-IVUS.<br>

Journal

• Internal Medicine

  Internal Medicine 50 (18), 1889-1894, 2011

  The Japanese Society of Internal Medicine

Keywords

• pigment epithelium-derived factor
• integrated backscatter intravascular ultrasound
• lipid volume
• fibrous volume

Details

• CRID: 1390001204871869696
• NII Article ID: 130000969292
• DOI: 10.2169/internalmedicine.50.5460
• ISSN: 13497235
• ISSN: 09182918
• Web Site: https://www.jstage.jst.go.jp/article/internalmedicine/50/18/50_18_1889/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012244086
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed