Good's Syndrome-Associated Pure Red Cell Aplasia with Myelodysplastic Syndrome

Access this Article

Search this Article

Author(s)

    • Nitta Hideaki
    • Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    • Harada Yuka
    • International Radiation Information Center, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    • Okikawa Yoshiko
    • Department of National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan
    • Arihiro Koji
    • Department of Anatomical Pathology, Hiroshima University, Japan
    • Kimura Akiro
    • Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    • Harada Hironori
    • Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan

Abstract

We report a case of Good's syndrome-associated pure red cell aplasia (PRCA) with myelodysplastic syndrome (MDS). In this case, effector memory T (T<sub>EM</sub>) cells were expanded in the bone marrow. It remains uncertain whether the development of MDS was caused by the basic marrow defects or radiation therapy. However, since CD8<sup>+</sup> perforin<sup>+</sup> T<sub>EM</sub> cells expanded in the bone marrow, as was previously described for 3 of our patients with thymoma-associated PRCA, it is highly possible that the pathogenic mechanism of PRCA that is accompanied by thymoma is related to the expanded CD8<sup>+</sup> perforin<sup>+</sup> T<sub>EM</sub> cells in this MDS-complicated case.<br>

Journal

  • Internal Medicine

    Internal Medicine 50(18), 2011-2014, 2011

    The Japanese Society of Internal Medicine

Codes

Page Top