Excess Copper Chelating Therapy for Wilson Disease Induces Anemia and Liver Dysfunction

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  • Harada Masaru
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Miyagawa Koichiro
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Honma Yuichi
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Hiura Masaaki
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Shibata Michihiko
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Matsuhashi Toru
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Abe Shintaro
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Harada Riko
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan
  • Tabaru Akinari
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan School of Medicine, Japan

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抄録

A 37-year-old man was diagnosed with Wilson disease at the age of 14. His first manifestations were neurological. He was treated with trientine for more than 10 years and suffered from anemia and liver dysfunction. Wilson disease is a genetic disorder characterized by accumulation of copper in the body. Excess copper is toxic, but copper is an essential trace element. Copper-binding ceruloplasmin is important for iron metabolism. Excess copper chelating treatment-induced anemia and iron deposition in the liver was suspected. Proper monitoring of copper status is important for the management of Wilson disease.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 50 (14), 1461-1464, 2011

    一般社団法人 日本内科学会

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