Intraarterial Concomitant Chemoradiation for Tongue Cancer: Analysis of 20 Patients

• Endo Sohei

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Suzuki Shin

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Tsuji Kenzo

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Niwa Hideo

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Noguchi Yugo

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Yoshida Kenji

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Kida Akinori

  Department of Otorhinolaryngology-Head and Neck Surgery, Nihon University School of Medicine

• Tanaka Yoshiaki

  Department of Radiology, Nihon University School of Medicine

• Himi Kazuhisa

  Department of Radiology, Nihon University School of Medicine

• Takemoto Akiko

  Department of Radiology, Nihon University School of Medicine

Bibliographic Information

Other Title

• 舌癌に対する超選択的動注併用照射療法の効果
• ゼツガン ニ タイスル チョウセンタクテキドウ チュウ ヘイヨウ ショウシャ リョウホウ ノ コウカ

Abstract

Subjects were 20 patients with tongue cancer treated between April 1996 and December 2002 with intraarterial infusion of cisplatin (60-120mg/m²) (and docetaxel 10-30mg/m²) and intravenous infusion of sodium thiosulfate followed by 5-fluorouracil (5-FU) (800-1000mg/m²) for 3 to 5 days. All patients underwent radiation (50-80 Gy). Ten had stage II, 4 stage III, and 6 stage IV A disease. Complete response at the primary site was achieved in 50% for T2, 67% for T3, and 0% for T4 lesions in those undergoing IA cisplatin followed by systemic 5-FU with concurrent radiation. Complete response at the primary site was achieved in all patients given IA cisplatin and docetaxel followed by systemic 5-FU with concurrent radiation. Disease-specific survival was 75% and overall survival 69% at 5 years. Side effects of treatment were tolerable, except for grade three radiomucositis in 70% of patients and grade three bone marrow depression in one treated with weekly LA chemotherapy.

Journal

• Nippon Jibiinkoka Gakkai Kaiho

  Nippon Jibiinkoka Gakkai Kaiho 108 (6), 689-693, 2005

  Japanese Society of Otorhinolaryngology-Head and neck surgery

Keywords

• tongue cancer
• intraarterial chemotherapy
• radiation
• cisplatin
• 5-FU
• docetaxel

Details

• CRID: 1390282679981722624
• NII Article ID: 130000992090
• NII Book ID: AN00191551
• DOI: 10.3950/jibiinkoka.108.689
• COI: 1:STN:280:DC%2BD2MzkvFOntQ%3D%3D
• ISSN: 18830854
• ISSN: 00306622
• NDL BIB ID: 7758429
• PubMed: 16001727
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7758429
• Web Site: https://search.jamas.or.jp/link/ui/2005200467
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed