書誌事項
- タイトル別名
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- THE EXPRESSION OF ICAM-1 ON HEAD AND NECK SQUAMOUS CELL CARCINOMA CELL LINES
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抄録
Intercellular adhesion molecule-1 (ICAM-1) is one of the cell adhesion molecules. This molecule is a glycoprotein of about 90 KDa belonging to the immunoglobulin (Ig) superfamily and is widely expressed by hematopoietic and non-hematopoietic cells which play a role in the immune system. ICAM-1 is also a ligand or counter-receptor for the leukocyte integrin lymphocytefunction associated antigen-1 (LFA-1).<BR>We investigated the expression of ICAM-1 on the surfaces of cells from fifteen head and neck squamous carcinoma cell lines and the modulation of ICAM-1 expression by IFN-γ, using an immunohistochemical stain. We categorized four types of stain degree.<BR>(-): <10% of cells positive (±): 10-40% of cells positive<BR>(+): <40-70% of cells positive (++): >70% of cells positive<BR>Four cell lines showed (-) type. Three cell lines: (±). One cell line: (+). Seven cell lines: (++).<BR>The primary site of cell lines and the degree of ICAM-1 expression were not detectable. Connection between pathological differentiation and the degreed expression were not apparent, either.<BR>IFN-γup-regulated the degree of ICAM-1. All cell lines, when stimulated by IFN-γ, showed (++) type.
収録刊行物
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- 日本耳鼻咽喉科学会会報
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日本耳鼻咽喉科学会会報 96 (5), 827-832_2,877, 1993
一般社団法人 日本耳鼻咽喉科頭頸部外科学会
