書誌事項
- タイトル別名
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- Chenodeoxycholic acid therapy for the dissolution of gallstones Its efficacy and safety
- 有効性ならびに安全性についての検討
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抄録
Thirty-nine patients having gallstones in a functioning gallbladder were treated with chenodeoxycholic acid (CDCA) for more 3 to 18 months. The dose of CDCA used was 500 or 300mg per day.<br>Twenty-one patients with radiolucent gallstones showed a definite response in gallstone size by this treatment. Complete dissolution of stones occurred in 13 patients and reduction in size in 8. The effect of CDCA on gallstones varied with stone size and the dose of CDCA. Gallstones of small and medium size (less than 10mm in diameter) were dissolved completely or partially in 16 out of 17 cases within one year with 500mg of CDCA per day, whereas this treatment had no effect in 4 patients with radiopaque gallstones and in 5 out of 6 patients with large radiolucent gallstones.<br>Diarrhoea occurred in 7 patients taking 500mg CDCA per day. A slight and transient elevation in SGOT, SGPT and alkaline phosphatase was seen in 8 patients. There was no histological evidence of hepatic injury induced by CDCA as studies on the liver biopsies of 12 patients. No significant changes were noted in the fasting serum cholesterol and triglyceride levels.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 73 (10), 1232-1246, 1976
一般財団法人 日本消化器病学会
