レーザードップラー法によるラット胃粘膜血流測定の検討  接触式水素ガスクリアランス法との比較

書誌事項

タイトル別名
  • CONTINUOUS MEASUREMENT OF GASTRIC MUCOSAL BLOOD FLOW BY LASER-DOPPLER VELOCIMETRY IN THE RAT
  • 接触式水素ガスクリアランス法との比較

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抄録

The application of the gastric mucosal blood flow measurement by the laser-Doppler velocimetry (LDV) was examined in rats by comparison with that by the hydrogen gas clearance technique (contact electrode method).<br>The laser-Doppler flow signal and the absolute gastric mucosal blood flow by the hydrogen gas clearance technique were significantly correlated (p<0.01). And the flow measurement by the LDV was reproducible in the same rat as long as the probe was pressed lightly against the same mucosa.<br>The LDV had the advantages that it yielded a continuous measurement in a small localized gastric mucosa, responding instantaneously to the delicated change of the mucosal flow, and that the LDV was able to measure the low blood flow which could not be recorded by the hydrogen gas clearance technique.<br>Therefore, the LDV has a good possibility of the application of the gastric mucosal blood flow measurement, and is very useful in the studies of the pathophysiology of the gastric mucosal blood flow that is one of the gastric mucosal defensive factors.

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