書誌事項
- タイトル別名
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- STUDIES ON LYMPHOKINES WHICH ENHANCE HEPATIC FIBROSIS IN CHRONIC LIVER DISEASES, DETECTED BY A SIMPLIFIED METHOD
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抄録
To examine a possible role of "fibrogenic factor", a kind of lymphokines, that enhances the collagen production by fibroblasts in the mechanism of hepatic fibrosis in chronic hepatitis, we devised a simplified 1-step method instead of the previously reported, standard 2-step method.<br>The activity of the fibrogenic factor (fibrogenic activity, FA) was assayed by adding both peripheral lymphocytes and liver specific lipoprotein (Meyer zum Büschenfelde's LSP) at the same time to L929 fibroblast culture system.<br>FA was assayed in 9 patients with chronic active hepatitis (CAH), 7 patients with chronic inactive hepatitis (CIH) and 8 healthy persons by both this simplified 1-step method and the standard 2-step method to ascertain the reliability of the 1-step method. The findings matched well in 22 out of 24 (92%) of these cases.<br>Next, FA was assayed by the 1-step method in a larger number of subjects. FA was detected in 8 of 12 (67%) patients with CAH, in 4 of 16 (25%) patients with CIH and in none of the 8 healthy persons. The positive frequency of FA in each group assayed by the 1-step method was similar to that by the 2-step method. The positive frequency of FA in CAH was significantly higher (p<0.01) as compared with healthy persons by the 1-step method as well as the 2-step method.<br>The above data suggest that "fibrogenic factor" may have a significant role in the mechanism of hepatic fibrosis in chronic active hepatitis, and that the relative simplicity of the 1-step method has proved to be clinically useful in detecting the fibrogenic factor.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 81 (1), 46-55, 1984
一般財団法人 日本消化器病学会