Clinical utility of receptor imaging in the assessment of liver function.
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- KUDO Masatoshi
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- IKEKUBO Katsuji
- Department of Nuclear Medicine, Kobe City General Hospital
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- TODO Akio
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- MIMURA Jun
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- OKABE Yoshihiro
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- KASHIDA Hiroshi
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- HIRASA Masahiro
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- IBUKI Yasuyoshi
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- TOMITA Shusuke
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- KOMORI Hideshi
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- ORINO Akio
- Division of Gastroenterology, Department of Internal Medicine, Kobe City General Hospital
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- HINO Megumu
- Department of Nuclear Medicine, Kobe City General Hospital
Bibliographic Information
- Other Title
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- レセプターイメージングによる肝機能評価 臨床的有用性の検討
- 臨床的有用性の検討
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Abstract
Technetium-99m diethylene triamine pentaacetic acid-galactosyl human serum albumin (TcGSA) is a newly developed receptor-binding radiopharmaceutical, specific for the asialogycoprotein receptor, which resides exclusively on the plasma membrane of hepatocytes. Clinical utility of TcGSA was evaluated in 3 control subjects with normal livers and in 54 patients with various liver diseases. The parameter, Receptor Index, was derived from liver and heart time-activity data and is the ratio of radioactivity of the liver over the radioactivity of the liver plus heart at 15min after the intravenous injection of 3mg of TcGSA. Receptor concentration ([R]o) was obtained by kinetic analysis of liver and heart time-activity data using pharmacokinetic nonlinear modeling. Values for the Receptor Index and [R]o were statistically different in the control subjects and in patients with mild, moderate, and severeliver diseases. Good correlations were obtained between the Receptor Index, [R]o and conventional liverfunction tests, such as Child-Turcotte criteria score, prothrombin time, and indocyanine green test. Receptor Index and [R]o were properly estimated even in patients with obstructive jaundice or remarkable portocaval shunt. These data suggest that the receptor imaging as well as its parameters, Receptor Index and [R]o, is a potentially practical and reliable diagnostic method for estimating the functioning hepatocyte mass and for assessing liver function.
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 89 (6), 1349-1359, 1992
The Japanese Society of Gastroenterology
