胃癌における消化管への蛋白漏出量の検討

• 中谷 尚登

  東邦大学医学部第1内科

書誌事項

タイトル別名

• Quantitative study of serum protein loss into the alimentary tract in patients with gastric cancer.

抄録

Quantitative study of serum protein loss into the alimentary tract from the tumor of gastric cancer using 111Indium-transferrin (¹¹¹In-Tf) was performed. Gamma counting of ¹¹¹In-Tf excreted in feces and ¹¹¹In-Tf scintigram were performed in 24 patients with gastric cancer and 10 controls. Transferrin was labelled by incubating 111MBq (3mCi) of ¹¹¹In chloride with approximately 13ml of patient plasma in vitro. After intravenous injection of ¹¹¹In-Tf, an aliquot was weighed and its radioactivity was measured in a gamma-counter. Feces were collected every 24hrs up to 72hrs. Then ¹¹¹In in the feces was calculated as a percentage of the injection dose.<BR> ¹¹¹In excreted in the feces within 72hrs in patients with gastric cancer was 3.711±3.87% (mean±SD), which was significantly higher than the 0.48±0.26% in 10 controls. ¹¹¹In in feces correlated the area of the tumor in the stomach (p<0.001). In 18 patients positive scan was recognized and was localized the protein loss in the cavity of the stomach within 10 minutes. Positive scan was found to move along the intestine successively.<BR> ¹¹¹In-Tf can be useful in assessing of hypoproteinemia of gastric cancer.

収録刊行物

• 日本消化器病学会雑誌

  日本消化器病学会雑誌 91 (9), 1391-1398, 1994

  一般財団法人 日本消化器病学会

キーワード

• 胃癌
• <SUP>111</SUP>In-トランスフェリン
• 蛋白漏出量
• シンチグラム

詳細情報

• CRID: 1390001206397461248
• NII論文ID: 130001070013
• DOI: 10.11405/nisshoshi1964.91.1391
• COI: 1:STN:280:ByqD3Mbit1w%3D
• ISSN: 13497693
• ISSN: 04466586
• PubMed: 7933636
• Web Site: https://search.jamas.or.jp/link/ui/1995028384
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可