Diagnostic Value of Serum Procalcitonin and C-reactive Protein for Infections after Allogeneic Hematopoietic Stem Cell Transplantation versus Nontransplant Setting

DOI Web Site 27 References
  • Mori Yasuo
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan Center for Cellular and Molecular Medicine, Kyushu University, Japan
  • Miyawaki Kohta
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
  • Kato Koji
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
  • Takenaka Katsuto
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
  • Iwasaki Hiromi
    Center for Cellular and Molecular Medicine, Kyushu University, Japan
  • Harada Naoki
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
  • Miyamoto Toshihiro
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan
  • Akashi Koichi
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Japan Center for Cellular and Molecular Medicine, Kyushu University, Japan
  • Teshima Takanori
    Center for Cellular and Molecular Medicine, Kyushu University, Japan

Search this article

Abstract

Objective Procalcitonin (PCT) has been increasingly used as a biomarker of infection. The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where non-infectious febrile complications such as graft-versus-host disease frequently develop.<br> Methods We retrospectively analyzed 144 febrile episodes (infections: 82, and noninfections: 62) in adult patients with hematological disorders, including 57 and 87 episodes in HSCT and non-HSCT patients, respectively.<br> Results Of 57 febrile episodes in HSCT patients, 46 (86%) and 25 (44%) revealed positivity for C-reactive protein (CRP) and PCT, respectively. Among 87 febrile episodes in non-HSCT patients, 81 (93%) and 22 (25%) events showed positive results of CRP and PCT. Both of these biomarkers were associated with infectious episodes in univariate analysis. Multivariate analysis showed that a high cut-off level (>9.5 mg/dL) of CRP was a better indicator for infections than PCT in HSCT patients, while PCT positivity was more diagnostic for infections than any cutoff CRP level in non-HSCT patients.<br> Conclusion It may be necessary to interpret the results of these biomarkers with different orders of priority in transplant versus nontransplant patients.<br>

Journal

  • Internal Medicine

    Internal Medicine 50 (19), 2149-2155, 2011

    The Japanese Society of Internal Medicine

References(27)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top