Pramipexole Reduces the Prevalence of Fatigue in Patients with Parkinson's Disease

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Author(s)

    • Morita Akihiko
    • Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan
    • Nogawa Shigeru
    • Department of Medicine, Tokyo Dental College Ichikawa General Hospital, Japan
    • Okuma Yasuyuki
    • Department of Neurology, Juntendo University Shizuoka Hospital, Japan
    • Kamei Satoshi
    • Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan
    • Yoshii Fumihito
    • Department of Neurology, Tokai University School of Medicine, Japan
    • Yamamoto Toshimasa
    • Department of Neurology, Faculty of Medicine, Saitama Medical University, Japan
    • Utsumi Hiroya
    • The Third Department of Internal Medicine, Division of Neurology, Tokyo Medical University, School of Medicine, Japan
    • Hatano Taku
    • Department of Neurology, Juntendo University School of Medicine, Japan

Abstract

<b>Objective</b> The aim of this multicenter cross-sectional study was to assess the relation between fatigue in a large number of Japanese patients with Parkinson's disease (PD) and drugs taken to treat PD.<br> <b>Method</b> We used the 16-item Parkinson Fatigue Scale (PFS-16), which was designed to assess fatigue exclusively associated with PD. Multiple logistic regression analyses were used to assess the relation between antiparkinson drugs and fatigue in PD.<br> <b>Results</b> A total of 350 non-demented PD patients were enrolled. Fatigue (PFS score of ≥4) was revealed in 319 patients (91%). Pramipexole was administered to 24% of PD patients. Multiple logistic regression analysis revealed that the administration of Pramipexole was significantly related to low rates of fatigue in PD patients with Hoehn and Yahr stage <3 (p=0.011, odds ratio=5.23, 95% confidence interval; 1.47-18.63).<br> <b>Conclusion</b> The reduced fatigue in PD patients was observed in taking Pramipexole.<br>

Journal

  • Internal Medicine

    Internal Medicine 50(19), 2163-2168, 2011

    The Japanese Society of Internal Medicine

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