Leukoencephalopathy Induced by Low-dose Methotrexate in a Patient with Rheumatoid Arthritis
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- Matsuda Masayuki
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Kishida Dai
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Kinoshita Tomomi
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Hineno Akiyo
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Shimojima Yasuhiro
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Fukushima Kazuhiro
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Ikeda Shu-ichi
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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抄録
We report a patient with rheumatoid arthritis (RA) who developed leukoencephalopathy while being treated with low-dose methotrexate (MTX). She suddenly developed loss of recent memory and left homonymous hemianopsia ascribable to the bilateral but right-predominant occipitotemporal lesions. Intravenous administration of dexamethasone and cessation of MTX quickly relieved her clinical symptoms. Low-dose MTX-induced leukoencephalopathy is a rare complication in RA, but is important with regard to the possibility of serious neurological sequellae.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 50 (19), 2219-2222, 2011
一般社団法人 日本内科学会