Utility of short-term variability of repolarization as a marker for monitoring: a safe exercise training in patients with cardiac diseases

• Nishi Isao

  Division of Cardiology, Tsukuba Memorial Hospital

• Sugiyama Atsushi

  Department of Pharmacology, School of Medicine, Toho University

• Takahara Akira

  Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University

• Kuroki Kenji

  Division of Cardiology, Tsukuba Memorial Hospital

• Igawa Masayuki

  Division of Cardiology, Tsukuba Memorial Hospital

• Enomoto Tsuyoshi

  Division of Cardiology, Tsukuba Memorial Hospital

• Iida Kaname

  Division of Cardiology, Tsukuba Memorial Hospital

• Koseki Susumu

  Division of Cardiology, Tsukuba Memorial Hospital

• Aonuma Kazutaka

  Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

書誌事項

タイトル別名

• Utility of Short-Term Variability of Repolarization as a Marker for Monitoring a Safe Exercise Training Program in Patients With Cardiac Diseases

抄録

In order to begin searching for new markers for safe exercise training in patients with cardiac diseases, we tested the sensitivity and reliability of the short-term variability of repolarization (STV_QT) in comparison with QT interval, QTc, and T_peak-T_end interval (T_p-e) in patients with cardiac diseases. <br>Nine patients (8 men, 1 woman; 58 ± 10 years) were enrolled. The cardiac rehabilitation (CR) program consisted of walking, bicycling on an ergometer, and calisthenics for 30-50 minutes/session and 3-5 sessions/week for 3 months. ECGs of 31 consecutive sinus beats were obtained before and after the CR program. RR and QT intervals were measured in the aVL lead. The mean orthogonal distance from the diagonal to the points of the Poincaré plots was determined using the following equation; STV_QT [= Σ |QT_n+1-QT_n/(30 × 2^1/2)], as a marker of temporal dispersion of repolarization. Also, T_p-e of 5 consecutive beats was measured as a marker of spatial dispersion.<br>No fatal arrhythmias were observed in the CR. No significant difference was observed in the RR or QT interval between at baseline and at the end of the CR program. Meanwhile, QTc, STV_QT and T_p-e decreased significantly from 429 ± 27 to 400 ± 17 (P < 0.01), from 6.8 ± 1.3 to 4.7 ± 1.4 msec (P < 0.001), and from 74.8 (61.2/79.1) to 64.8 (51.4/70.7) msec (median (25th/75th percentile), P < 0.01), respectively.<br>STV_QT together with T_p-e and QTc may reflect the time-courses of safe exercise training.

収録刊行物

• International Heart Journal

  International Heart Journal 52 (5), 304-307, 2011

  一般社団法人 インターナショナル・ハート・ジャーナル刊行会

キーワード

• Beat to beat variability of repolarization
• Temporal dispersion
• Spatial dispersion
• Repolarization reserve
• Cardiac rehabilitation

詳細情報

• CRID: 1390282680203394304
• NII論文ID: 130001088314
• NII書誌ID: AA12013242
• DOI: 10.1536/ihj.52.304
• ISSN: 13493299
• ISSN: 13492365
• HANDLE: 2241/114840
• Web Site: https://tsukuba.repo.nii.ac.jp/records/25888
• Web Site: http://www.jstage.jst.go.jp/article/ihj/52/5/52_5_304/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012152579
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可