Cytotoxic Characteristics of Two Isomeric Dimers Produced by Oxidation of Sesamol, an Antioxidant in Sesame Oil

この論文にアクセスする

この論文をさがす

著者

    • Fujimoto Aya Fujimoto Aya
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Saito Minoru
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Kanemaru Kaori
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Masuda Toshiya
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
    • Oyama Yasuo
    • Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima

抄録

Antioxidants themselves are oxidized to prevent oxidation of other molecules. One may ask if the oxidized antioxidants are safe for humans. However, there is very little information on the toxicity of oxidized antioxidants. We previously identified cytotoxic compounds in the products from oxidation of sesamol, a potent antioxidant in sesame oil. In this study using a flow cytometer with fluorescent probes, we revealed cytotoxic characteristics of two isomeric dimers (dimer A and B) in rat thymocytes. Increase in cell lethality by dimer A was more profound than those by sesamol and dimer B. The incubation of cells with dimer A increased the populations of shrunken cells and the cells with phosphatidylserine exposed on outer surface of cell membranes. Since these phenomena are parameters for early stage of apoptosis, the results indicate that dimer A may promote the process of apoptosis. However, the population of the cells containing hypodiploid DNA, a parameter for late stage of apoptosis, was decreased by the incubation with dimer A. It was not the case for dimer B. Results indicate that dimer A may inhibit the degradation of DNA during apoptosis. Taken together, it is likely that dimer A exerts both proapoptotic action and inhibitory action on late stage of apoptosis in rat thymocytes.

収録刊行物

  • JOURNAL OF HEALTH SCIENCE

    JOURNAL OF HEALTH SCIENCE 57(5), 425-431, 2011

    公益社団法人 日本薬学会

各種コード

  • NII論文ID(NAID)
    130001151384
  • NII書誌ID(NCID)
    AA11316464
  • 本文言語コード
    ENG
  • ISSN
    1344-9702
  • NDL 記事登録ID
    11250174
  • NDL 雑誌分類
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL 請求記号
    Z54-J464
  • データ提供元
    NDL  J-STAGE 
ページトップへ