Absorption and Excretion of Ascorbic Acid Alone and in Acerola (Malpighia emarginata) Juice: Comparison in Healthy Japanese Subjects

DOI Web Site Web Site 3 Citations 19 References
  • Uchida Eriko
    Research and Development Division, Nichirei Foods Inc.
  • Kondo Yoshitaka
    Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology
  • Amano Akiko
    Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology Cellular Genetics Laboratory, Graduate School of Science and Engineering, Tokyo Metropolitan University
  • Aizawa Shingo
    Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology Cellular Genetics Laboratory, Graduate School of Science and Engineering, Tokyo Metropolitan University
  • Hanamura Takayuki
    Research and Development Division, Nichirei Foods Inc.
  • Aoki Hitoshi
    Research and Development Division, Nichirei Foods Inc.
  • Nagamine Kenichi
    Research and Development Division, Research and Development Center, Nichirei Bioscience Inc.
  • Koizumi Takeshi
    Research and Development Division, Nichirei Foods Inc.
  • Maruyama Naoki
    Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology
  • Ishigami Akihito
    Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology

Search this article

Abstract

It has been suggested that some food components, such as bioflavonoids, affect the bioavailability of ascorbic acid in humans. Since little is known in Japan about the effective intake of this dietary requirement, we tested young Japanese males after the ingestion of commercial ascorbic acid or acerola (Malpighia emarginata DC.) juice to compare the quantities absorbed and excreted. Healthy Japanese subjects received a single oral dose of ascorbic acid solution (50, 100, 200 or 500 mg) and received distilled water as a reference at intervals of 14 d or longer. All subjects were collected blood and urine until 6 h after ingestion and evaluated for time-dependent changes in plasma and urinary ascorbic acid levels. Predictably, the area under the curve (AUC) values in plasma and urine after ingestion increased dose-dependently. Next, each subject received diluted acerola juice containing 50 mg ascorbic acid. Likewise, their plasma and urinary ascorbic acid concentrations were measured. In plasma, the AUC value of ascorbic acid after ingestion of acerola juice tended to be higher than that from ascorbic acid alone. In contrast, the urinary excretion of ascorbic acid at 1, 2 and 5 h after ingestion of acerola juice were significantly less than that of ascorbic acid. These results indicate that some component of acerola juice favorably affected the absorption and excretion of ascorbic acid.

Journal

Citations (3)*help

See more

References(19)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top