The Relationship between Treatment Time of Gemcitabine and Development of Hematologic Toxicity in Cancer Patients
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- Iwata Kazufumi
- Department of Pharmacy, Kumamoto Red Cross Hospital Department of Pharmacy, Kumamoto University Hospital
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- Aizawa Keiji
- Department of Pharmacy, Kumamoto Red Cross Hospital
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- Sakai Saori
- Department of Pharmacy, Kumamoto Red Cross Hospital
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- Jingami Sachiko
- Department of Pharmacy, Kumamoto Red Cross Hospital
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- Fukunaga Eiko
- Department of Pharmacy, Kumamoto Red Cross Hospital
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- Yoshida Minoru
- Department of Medical Oncology, Kumamoto Red Cross Hospital
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- Hamada Akinobu
- Department of Pharmacy, Kumamoto University Hospital
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- Saito Hideyuki
- Department of Pharmacy, Kumamoto University Hospital
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抄録
Although gemcitabine is frequently used in the treatment of cancer, it is associated with myelosuppression. An animal study showed that the tolerability of gemcitabine varied with changes in treatment time; however, no clinical data have verified this finding. The purpose of this study was to determine the relationship between treatment time and development of hematologic toxicity in patients treated with gemcitabine. Gemcitabine-induced hematologic toxicity was retrospectively investigated in 77 patients. Patients were divided into two treatment-time groups: 9:00 and 15:00. Hematologic toxicity was evaluated on day 8 and 15 after treatment. On day 8 and 15, the changing count of white blood cells was significantly reduced in patients treated at 15:00 compared with those treated at 9:00 (p<0.01 and p<0.05, respectively). On days 8 and 15, the changing count of platelet was significantly reduced in patients treated at 15:00 compared with those treated at 9:00 (p<0.05). The incident of over common terminology criteria for adverse events (CTCAE) grade 2 white blood cell decreased was significantly reduced in patients treated at 15:00 compared with those treated at 9:00 (p=0.048, odds ratio=2.92). In conclusion, this cohort study demonstrated that gemcitabine-induced hematologic toxicity could be alleviated by treating patients at 9:00.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 34 (11), 1765-1768, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679608435456
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- NII論文ID
- 130001252863
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 11291457
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可