Impairment of Pulmonary Function is an Independent Risk Factor for Atrial Fibrillation: The Takahata Study

• Nemoto Takako

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Shibata Yoko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Osaka Daisuke

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Abe Shuichi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Inoue Sumito

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Tokairin Yoshikane

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Igarashi Akira

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Yamauchi Keiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Kimura Tomomi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Kishi Hiroyuki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Nishiwaki Michiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Aida Yasuko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Nunomiya Keiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Sato Masamichi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Watanabe Tetsu

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Konta Tsuneo

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Kawata Sumio

  Department of Gastroenterology, Yamagata University School of Medicine, Japan

• Kato Takeo

  Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Yamagata University School of Medicine, Japan

• Kayama Takamasa

  Department of Neurosurgery, Yamagata University School of Medicine, Japan

• Kubota Isao

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

書誌事項

タイトル別名

• Impact of Cigarette Smoking on Maximal Expiratory Flows in a General Population: the Takahata Study

抄録

Background Maximal expiratory flows (MEFs) depend on the elastic recoil pressure in the alveoli, airway resistance and bronchial collapsibility. MEFs at lower levels of vital capacity [MEFs at x% FVC (MEF_x)] would indicate the patency of peripheral airways. In Japan, a ratio of MEF₅₀ to MEF₂₅ (MEF₅₀/MEF₂₅) greater than 4.0 is used as an index of injury to the small airways in subjects without airflow limitation. However, to date there have been no epidemiological investigations relating to this index. The aim of this study was to evaluate the impact of cigarette smoking on MEFs in a general population, and to assess the validity of using this index to evaluate injury to the small airways.<br> Methods Subjects aged 40 years or older (n=2,917), who had participated in a community-based annual health-check in Takahata, Japan, were enrolled in the study. MEF₇₅, MEF₅₀ and MEF₂₅ were measured in these subjects.<br> Results In smokers, as compared with never-smokers, the percentage predicted MEFs (%MEFs) decreased according to the aging of the population, except in the case of %MEF₂₅ in females. In males, but not in females, %MEFs decreased significantly with an increase in cigarette consumption. In both genders, MEF₅₀/MEF₂₅ was slightly, but significantly, elevated with aging of the population. In addition, 36.5% of subjects who participated in this health-check had MEF₅₀/MEF₂₅ values greater than 4.0. No difference in MEF₅₀/MEF₂₅ was observed between smokers and never-smokers.<br> Conclusion Cigarette smoking enhanced the age-related decline in MEFs. Since many healthy subjects aged 40 years or older have MEF₅₀/MEF₂₅ values greater than 4.0, the use of this criterion may over-estimate the presence of small airway disease.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 50 (21), 2547-2555, 2011

  一般社団法人 日本内科学会

キーワード

• maximal expiratory flow
• cigarette smoking
• community-based health check
• spirometry
• small airway injury

詳細情報

• CRID: 1390282679847380992
• NII論文ID: 130001288610
• NII論文ID: 20001692397
• DOI: 10.2169/internalmedicine.50.5948
• DOI: 10.7150/ijms.8.514
• ISSN: 13497235
• ISSN: 09182918
• ISSN: 14491907
• Web Site: http://www.medsci.org/v08p0514.htm
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/50/21/50_21_2547/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012323362
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
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