Neuromyelitis Optica in Japanese Sisters

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  • Tanaka Yuji
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan The First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Japan
  • Yoshikura Nobuaki
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Harada Naoko
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Yamada Megumi
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Koumura Akihiro
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Sakurai Takeo
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Hayashi Yuichi
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Kimura Akio
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Hozumi Isao
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan
  • Moriwaki Hisataka
    The First Department of Internal Medicine, Graduate School of Medicine, Gifu University, Japan
  • Inuzuka Takashi
    Department of Neurology and Geriatrics, Graduate School of Medicine, Gifu University, Japan

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We report cases of Japanese sisters with neuromyelitis optica (NMO). The elder sister was 25, when she was diagnosed with right optic neuritis. After 3 months, she developed left optic neuritis and myelitis. At age 27, she had the second relapse, but she has been free from episodes thereafter. The younger sister was 26, when she was diagnosed with optic neuritis. Thus far, she has 9 relapses, comprising both myelitis and optic neuritis. Both sisters had normal brain MRI scans, longitudinally extensive transverse myelitis over 3 vertebral segments, and positive results for anti-aquaporin-4 antibody (AQAP4Ab). They fulfilled the Wingerchuk criteria for definite NMO. Both sisters shared some immunogenetic factors, but they were not exposed to the same environmental factors after their early twenties. The final disability status was almost the same in both cases, and both showed a very benign course. These data suggest that genetic factors affect the age at onset and environmental factors may affect the frequency of relapse.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 50 (22), 2829-2832, 2011

    一般社団法人 日本内科学会

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