Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction

• Unno Keiko

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Yamamoto Hiroyuki

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Ohtaki Toshiya

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Ishikawa Yuichi

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Noda Shigenori

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Maeda Ken-ichi

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Fujitani Keisuke

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Miyazaki Hideaki

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

• Takabayashi Fumiyo

  Junior College, University of Shizuoka

• Sasaki Toru

  Research Team for Molecular Biomarker, Tokyo Metropolitan Institute of Gerontology

• Hoshino Minoru

  Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka

抄録

Objective: We previously found that green tea catechins (GT-catechin) decrease oxidative damage to DNA and suppress brain dysfunction in aged senescence-accelerated mice (SAMP10). To clarify the effect of GT-catechin on suppression of brain dysfunction, we compare the effect on learning ability among several catechins and examined the essential intake period for prevention of brain dysfunction.<br>Methods: Male SAMP10 mice were allowed free access to water containing epigallocatechin gallate (EGCG, 0.06 mg/ml), epigallocatechin (EGC, 0.03 mg/ml), GT-catechin (0.2 mg/ml), or green tea extract (0.66 mg/ml). Learning ability of mice was measured using a step-through passive avoidance task.<br>Results: SAMP10 mice exhibit brain dysfunction with aging. However, learning ability was significantly higher in mice that drank GT-catechin and EGCG than same-aged control mice that drank water. EGCG was an important component, but EGC had no effect on learning ability. The learning ability was significantly improved in mice that ingested EGCG for > 5 months, and tended to improve in mice that ingested EGCG for 2 or 3 months. Next, the level of synaptophysin, a marker of presynapse, tended to be higher in mice that ingested EGCG but not in mice that ingested EGC. The levels of synaptophysin were significantly higher in mice ingested GT-catechin and green tea extract than control mice.<br>Conclusion: The intake of EGCG, the major catechin in green tea, but not EGC, suppressed age-related brain dysfunction. The effective intake period of EGCG was > 5 months for suppression of brain dysfunction.

収録刊行物

• ＡＮＴＩ‐ＡＧＩＮＧ　ＭＥＤＩＣＩＮＥ

  ＡＮＴＩ‐ＡＧＩＮＧ　ＭＥＤＩＣＩＮＥ 8 (6), 75-81, 2011

  一般社団法人 日本抗加齢医学会

キーワード

• green tea catechin
• brain dysfunction
• epigallocatechin gallate
• intake period
• synaptic plasticity

詳細情報

• CRID: 1390001205295810048
• NII論文ID: 130001290311
• DOI: 10.3793/jaam.8.75
• ISSN: 18822762
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可