口腔へん平上皮癌患者に対する術前ＭＦ療法の検討

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  • Preoperative MTX/5-FU therapy for oral squamous cell carcinoma.

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Twenty-five patients with oral squamous cell carcinomas were treated initially with methotrexate 75mg/body followed 1 hour later by 5-fluorouracil 500 mg/body twice a week. Treatments were repeated every 7 days for 2 weeks.<BR>1. Of 25 evaluable patients with squamous cell carcinoma, 17 (68%) achieved a partial (12) or complete (5) response, and 4 (16%) achieved minor response.<BR>2. Histopathological effect was found in 18 (72%) patients.<BR>3. Down-Stage rate was 72%.<BR>4. Clinical effect for cervical lymph nodes metastases was 75%, and in 2 out of 8 patients cervical lymph node metastases disappeared histopathologically.<BR>5. The recurrence rate of primary lesions was 12%, the metastasis rate of cervical lymph node was 8%, the distant metastasis rate was 4%, and the total recurrence and/or metastasis rate was 24%.<BR>6. Side effects were slight, and severe leukopenia, mucositis, and kidney disorders were not observed.<BR>7. The 5 year survival rate was 74.7%, and it was higher than that of surgery alone (58.4%) and that of preoperative radiotherapy-surgery (55.5%).<BR>This observation suggests that patients with oral squamous cell carcinoma were sensitive to initial MTX/5-FU therapy (MF therapy) and preoperative chemotherapy provide a good prognosis.

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