ヘルペス性歯肉口内炎および口腔内に症状を示した帯状ほう疹の臨床ならびに病理学的,電顕的検討

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  • Clinico-histological and electron microscopic investigations of herpetic gingivostomatitis and herpes zoster with oral lesions.

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We examined 23 patients with hcrpetic gingivostomatitis and 3 with herpes zoster presenting oral signs from February, 1985 to November, 1989 in our department.<BR>1. In herpetic gingivostomatitis the affected age was above 20 in 18 cases accounting for 78.2% and the initial infection did not always occur in infancy and childhood. Initial infection was liable to occur in adolescence and adulthood and the recurrent type was frequently observed. Hunts syndrome was observed in one of the herpes zoster cases.<BR>2. The disease type of herpetic gingivostomatitis was unclear and a relationship between the disease type and the course of signs was suspected. Unclear signs of gingivitis were observed in 4 cases. The oral signs of herpes zoster occurred almost simultaneously and ipsilaterally with eruption.<BR>The chief complaint in all cases was either contact pain or eating disorder.<BR>3. The histopathological image revealed ballooning degeneration of the vesicle wall and vesicle formation in the epitherial membrane in both diseases, and an intranuclear inclusion body as observed.<BR>In the electron microscopical image, HSV and VZV were 150-200 nm in diameter and were of various types including the immature type in monocircular form and the mature type showing a triple structure, and the mature type was frequently observed in the fibrin tissue and intercellular space.<BR>Cells presumed to be the intranuclear inclusion body were filled up with immature viruses. The type in which several microcircle structures with a central core morphology different from that of HSV was included in the VZV.

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