口腔へん平苔せんの臨床病理学的所見と免疫担当細胞の分布様相との関連について

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  • Relationship between clinicopathological variants and the density and distribution of immunocompetent cells in oral lichen planus.

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Thirty adults diagnosed having oral lichen planus were studied in order to compare clinicopathological variants with the density and distribution of immunocompetent cells in oral lichen planus. It is generally accepted that the immunohistological findings of lichen planus are similar to those of lymphokine-generated inflammation. However, the oral lesions of lichen planus demonstrate rather marked variations in clinical appearance as well as in microscopic pathological staging.<BR>In the present study, an attempt is made to subdivide all specimens into various clinicopathological categories (a. site of biopsy b. suffering period clinical type d. degree of epithelial atrophy e. degree of basal cell damage f. density of infiltrating mononuclear cells), and to analyze the correlation with the density and distribution of T cell subsets, ANAE+macrophages, and Langerhans cells.<BR>1. There was no correlation of the density of any immunocompetent cells with both site of biopsy and age of the lesion.<BR>2. In reticular lichen planus, Leu 2 a+ T cells (cytotoxic/suppressor T cells) were concentrated within and beneath the epithelium. On the other hand, the erosive forms of the lesion showed Leu 3 a/3 b + T cells (helper/inducer T cells) densely distributed throughout the stratum proprium.<BR>3. There was no significant correlation between severity of basal cell damage and frequency of Leu 4+ T cell (pan T cell), but the density of Leu 2 a+ T cell infiltration was higher in “moderate/marked” than in “mild” basal cell damage.<BR>4. This study revealed no correlation between the density of HLA-DR/DQ+ and T 6+cells and any clinicopathological variants. More data is needed before providing a solid conclusion.

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