骨適合性を有する多相系生医学材料に関する研究 ＩＩＩ ハイドロキシアパタイト‐ポリマー複合材料の細胞培養試験:第3報ハイドロキシアパタイト-ポリマー複合材料の細胞培養試験 [in Japanese] Study on multiphase biomedical materials compatible with bone tissue. Part 3. A cell culture test of hydroxyapatite-polymer composite material.:Part 3. A cell culture test of hydroxyapatite-polymer composite material [in Japanese]
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Implant materials which serve as substitutes for hard tissues such as teeth and mandibles must satisfy many criteria including biochemical compatibility, biomechanical compatibility, and ease of processing and handling.<BR>The authors et al. have developed multiphase materials consisting of hydroxyapatite [HAP] particles (8μ or 7μ average diameter), poly (2, 2, 2-trifluoroethyl methacrylate)(PTFEMA) or poly (methyl methacrylate)[PMMA] around a metal core in order to obtain an implant material which easily satisfies all the proposed criteria.<BR>The purpose of this study is to evaluate the biochemical compatibility of these multiphase materials. HAP-70 wt% polymer composite materials were placed on the interfacial layer of multiphase materials in direct contact with living tissue. In order to evaluate biochemical compatability, the HAP-polymer composite was examined using a direct contact method cell culture test which measured cytotoxity and cell adhesiveness. As controls, both homopolymers of PTFEMA and PMMA, and HAP dense ceramics were also examined.<BR>Consequently, <BR>(1) Neither PTFEMA nor PMMA demonstrated cytotoxity, but each tended to require more time for cell spreading and cell growth on the surface than HAP dense ceramics.<BR>(2) HAP dense ceramics showed high degrees and rates of cell adhesiveness and growth.<BR>(3) Both HAP-polymer composite materials, containing either PTFEMA or PMMA showed essentially the same cell adhesiveness and growth pattern as HAP dense ceramics.<BR>These results indicate the safety and suitability of these multiphase materials for use as implant materials when hard tissue substitutes are required.
- Japanese Journal of Oral and Maxillofacial Surgery
Japanese Journal of Oral and Maxillofacial Surgery 34(4), 618-626, 1988
Japanese Society of Oral and Maxillofacial Surgeons